Craig Mayer, Nick WIlliams, Vojtech Huser
Lister Hill National Center for Biomedical Communications, National Library of Medicine, NIH, Bethesda, MD

See the full regCTG repository at https://github.com/lhncbc/CRI/tree/master/regCTG

To return to the list of conditions and view other reports go to https://lhncbc.github.io/CRI/regCTG/regCTG-condition_report_links.html


Study Counts

Type Study_count
Total_Studies 1291
interventional 1043
Observational 238
Registry 10

Studies over Time

```

Interventional Trials

Intervention Type

intervention_type Study_Count
Drug 521
Behavioral 202
Drug|placebo 78
Other 51
Biological 47
Device 23
Behavioral|Other 18
Procedure 13
Biological|placebo 10
Dietary Supplement|placebo 10
Dietary Supplement 8
Combination Product 7
Diagnostic Test 7
Drug|Other 7
Behavioral|Drug 6
Device|Other 4
Drug|Other|placebo 3
Biological|Drug|placebo 2
Biological|Other 2
Dietary Supplement|Drug 2
Drug|Procedure 2
Behavioral|Biological 1
Behavioral|Device|Procedure 1
Behavioral|Diagnostic Test|Drug 1
Behavioral|Diagnostic Test|Procedure 1
Behavioral|Dietary Supplement 1
Behavioral|Other|Procedure 1
Behavioral|Procedure 1
Biological|Device 1
Biological|Drug 1
Biological|Drug|Other 1
Combination Product|Device 1
Combination Product|Drug 1
Combination Product|placebo 1
Device|Drug 1
Device|placebo 1
Dietary Supplement|Drug|placebo 1
Drug|Genetic 1
Drug|Radiation 1
Genetic 1
Other|placebo 1

Count of Studies by Intervention (normalized and mapped)

Interventions over Time

Weekly studies for each intervention

Studies by Country

Country Study_Count
United States 509
NA 71
United States|Puerto Rico 37
South Africa 31
Canada 20
Kenya 20
Uganda 20
United Kingdom 17
Thailand 15
Brazil 12
China 11
Spain 11
United States|Canada 10
France 9
Germany 8
Tanzania 8
Australia 7
Malawi 7
Switzerland 7
Lesotho 6
Mexico 6
Belgium 5
Mozambique 5
India 4
United States|Canada|Puerto Rico 4
Argentina 3
Botswana 3
Denmark 3
Ireland 3
Italy 3
Nigeria 3
Russian Federation 3
Senegal 3
Singapore 3
Taiwan 3
Vietnam 3
Zambia 3
Zimbabwe 3
Burkina Faso|Côte D’Ivoire|Mali|Togo 2
Cameroon 2
Estonia 2
Ethiopia 2
Ghana 2
Indonesia 2
Netherlands 2
Romania 2
Rwanda 2
Swaziland 2
United States|South Africa 2
United States|Tanzania 2
|United States|Italy|Puerto Rico 1
Argentina|Brazil|Canada|United Kingdom 1
Argentina|Brazil|India|Kenya|South Africa 1
Argentina|France|South Africa|United States|Thailand 1
Australia|Brazil|France|Poland|Russian Federation|Spain|Sweden|United Kingdom 1
Australia|France|Germany|Italy|Spain|United Kingdom 1
Australia|United States|American Samoa 1
Austria 1
Austria|Belgium|Denmark|France|Germany|Hungary|Ireland|Israel|Poland|Spain|Sweden|Switzerland|United Kingdom 1
Austria|Belgium|Denmark|France|Germany|Ireland|Italy|Latvia|Netherlands|Portugal|Spain|Switzerland|United Kingdom 1
Austria|Belgium|Denmark|Germany|Hungary|Israel|Portugal|Russian Federation|Spain|Switzerland|United Kingdom 1
Austria|Denmark|France|Germany|Hungary|Israel|Romania|Russian Federation|Spain|Switzerland|United Kingdom 1
Belgium|France|Germany|Ireland|Italy|Spain|United Kingdom 1
Belgium|France|Germany|Italy|Romania|Russian Federation|Spain|Switzerland|United Kingdom 1
Belgium|Netherlands 1
Brazil|Estonia|India|Thailand 1
Bulgaria 1
Cambodia 1
Cambodia|Thailand 1
Cameroon|Kenya|Senegal|South Africa|Thailand|Uganda 1
Chile|France|United States|Argentina|Australia|Austria|Brazil|Germany|Guatemala|Hungary|Malaysia|Panama|Puerto Rico|Romania|South Africa|Spain|Taiwan|Thailand|United Kingdom 1
China|Korea, Republic of 1
China|Korea, Republic of|Singapore 1
Congo, The Democratic Republic of the 1
Ecuador 1
France|Canada 1
Georgia 1
Germany|Ireland|Netherlands|Thailand|United Kingdom 1
Germany|Netherlands 1
Germany|United Kingdom 1
Haiti 1
India|Malawi|South Africa|Tanzania|Uganda|Zambia|Zimbabwe 1
India|South Africa|Uganda 1
Iran, Islamic Republic of 1
Israel 1
Italy|United States|France|Germany|South Africa|Spain 1
Jamaica 1
Japan 1
Kazakhstan 1
Kenya|Malawi|Rwanda|South Africa|Tanzania 1
Kenya|Malawi|Uganda|Zambia|Zimbabwe 1
Kenya|Malawi|Uganda|Zimbabwe 1
Kenya|Tanzania|Thailand|Uganda 1
Kenya|Zimbabwe 1
Korea, Republic of 1
Mauritius|Thailand 1
Nepal 1
Norway 1
Peru 1
Puerto Rico|United States 1
South Africa|Tanzania 1
South Africa|Tanzania|Uganda|Zambia 1
South Africa|Thailand 1
South Africa|Thailand|Ukraine 1
South Africa|Uganda|Zambia 1
South Africa|Uganda|Zimbabwe 1
South Africa|Zimbabwe 1
Spain|Sweden|Switzerland|Puerto Rico|United States|Belgium|Canada|France|Poland|United Kingdom 1
Sweden 1
Thailand|Argentina|Brazil|Mexico|Peru|Russian Federation|South Africa 1
Uganda|Zimbabwe 1
United States|Argentina|Australia|Austria|Belgium|Brazil|Chile|Czechia|Denmark|Estonia|Finland|France|Germany|Greece|India|Ireland|Israel|Italy|Luxembourg|Malaysia|Mali|Mexico|Morocco|Nigeria|Norway|Peru|Poland|Portugal|Puerto Rico|South Africa|Spain|Sweden|Switzerland|Thailand|Uganda|United Kingdom 1
United States|Argentina|Australia|Austria|Brazil|Canada|Denmark|France|Mexico|Netherlands|Portugal|Puerto Rico|Romania|Russian Federation|South Africa|Spain|Sweden|Taiwan|Thailand|United Kingdom 1
United States|Argentina|Australia|Belgium|Brazil|Canada|Chile|France|Greece|Hungary|Italy|Mexico|Netherlands|Poland|Romania|Russian Federation|South Africa|Spain|Taiwan|United Kingdom 1
United States|Argentina|Australia|Belgium|Canada|France|Germany|Italy|Korea, Republic of|Mexico|Netherlands|Portugal|Romania|Russian Federation|South Africa|Spain|Taiwan|United Kingdom 1
United States|Argentina|Australia|Belgium|Canada|France|Germany|Italy|Mexico|Peru|Poland|Portugal|Romania|Russian Federation|Spain|Switzerland|Taiwan|United Kingdom 1
United States|Argentina|Australia|Canada|France|Germany|Italy|Korea, Republic of|Mexico|Russian Federation|South Africa|Spain|Sweden 1
United States|Argentina|Austria|Brazil|China|France|Germany|Mexico|Puerto Rico|Russian Federation|South Africa|Thailand|Uganda|United Kingdom 1
United States|Argentina|Brazil|Puerto Rico|South Africa 1
United States|Argentina|Canada|France|Italy|Mexico|Portugal|Puerto Rico|Russian Federation|South Africa|Spain|Thailand|United Kingdom 1
United States|Argentina|Colombia|Germany|Mexico|Peru|Romania|Russian Federation|South Africa|Spain 1
United States|Argentina|France|Guatemala|Mexico|Peru|Puerto Rico|Romania|Russian Federation|South Africa|Ukraine 1
United States|Argentina|Mexico|Portugal|Puerto Rico|Russian Federation|South Africa 1
United States|Argentina|South Africa|Thailand|United Kingdom 1
United States|Australia 1
United States|Australia|Austria|Belgium|Canada|France|Germany|Italy|Portugal|Puerto Rico|Spain|United Kingdom 1
United States|Australia|Austria|Canada|Dominican Republic|Germany|Mexico|Puerto Rico|United Kingdom 1
United States|Australia|Belgium|Canada|Czech Republic|France|Germany|Greece|Ireland|Italy|Netherlands|Poland|Puerto Rico|Russian Federation|Singapore|Spain|Switzerland|Taiwan|United Kingdom 1
United States|Australia|Belgium|Canada|Denmark|France|Germany|Italy|Netherlands|Romania|Spain|United Kingdom 1
United States|Australia|Canada|Denmark|France|Germany|Italy|Sweden|Switzerland|United Kingdom 1
United States|Australia|Canada|France|Germany|Italy|Russian Federation|Spain|United Kingdom 1
United States|Australia|Canada|France|Puerto Rico 1
United States|Australia|Puerto Rico 1
United States|Austria|Belgium|Canada|France|Germany|Italy|Latvia|Luxembourg|Poland|Portugal|Romania|Spain|Switzerland 1
United States|Austria|Belgium|Canada|France|Germany|Italy|Portugal|Puerto Rico|Spain|Switzerland|United Kingdom 1
United States|Bahamas|Brazil|Puerto Rico 1
United States|Belgium|Canada|France|Germany|Italy|Portugal|Spain|United Kingdom 1
United States|Belgium|Canada|Romania|Russian Federation|South Africa|Spain 1
United States|Belgium|Dominican Republic|France|Italy|Mexico|Portugal|Puerto Rico|Russian Federation|Thailand|Uganda|United Kingdom 1
United States|Botswana 1
United States|Brazil|Chile|France|Italy|Portugal|Spain|United Kingdom 1
United States|Brazil|Italy|Mexico|Portugal|Puerto Rico|South Africa|Spain|Thailand 1
United States|Canada|France|Germany|Portugal|Puerto Rico|Spain|United Kingdom 1
United States|Canada|France|Germany|Spain 1
United States|Canada|France|Italy|Poland|Puerto Rico|Spain 1
United States|Canada|France|Italy|Spain 1
United States|Canada|Netherlands|Puerto Rico 1
United States|Costa Rica|Panama|Puerto Rico 1
United States|Denmark|Germany 1
United States|Dominican Republic|Russian Federation|Thailand|Uganda 1
United States|France|Germany|Italy|Puerto Rico|Romania|Russian Federation|Spain|Switzerland 1
United States|France|Germany|Italy|Russian Federation|Spain 1
United States|France|United Kingdom 1
United States|Germany 1
United States|Germany|Spain 1
United States|Italy 1
United States|Kazakhstan 1
United States|Kenya|Puerto Rico|South Africa 1
United States|Mexico 1
United States|Netherlands 1
United States|Puerto Rico|Tanzania 1
United States|Russian Federation 1
United States|Rwanda 1
United States|South Africa|Thailand 1
United States|South Africa|Thailand|Uganda|Zimbabwe 1
United States|South Africa|Zimbabwe 1
United States|Spain|Belgium|Canada|France|Italy|Portugal 1
United States|Uganda 1
United States|Zambia 1
Zimbabwe|United States|Malawi|South Africa|Zambia 1

Sites per Study

Site_count Study_Count
1 632
2 87
3 37
4 29
5 25
6 14
7 14
8 11
9 11
10 5
11 7
12 10
13 4
14 7
15 8
16 3
17 9
18 8
19 6
20 4
21 3
22 3
23 4
24 3
25 2
26 3
27 1
28 4
30 2
32 3
34 3
35 3
36 3
37 5
39 3
40 2
41 2
42 1
43 1
44 3
45 3
46 2
47 3
48 2
49 2
50 1
51 3
52 3
54 3
56 2
60 1
62 1
66 1
67 1
68 2
69 1
71 2
72 1
75 1
76 2
80 2
82 1
87 2
89 2
90 1
95 1
96 1
99 2
101 1
103 1
105 1
115 1
120 1
129 1
145 1
180 1
218 1

Phase

Phase Study_Count
N/A 378
Phase 1 224
Phase 2 162
Phase 3 148
Phase 4 80
Phase 1/Phase 2 27
Phase 2/Phase 3 18
Early Phase 1 6

Number of Arms

Number_of_Arms Count_of_Studies
1 179
2 420
3 85
4 46
5 17
6 9
7 2
8 4
9 4
10 1
11 2
12 1
13 1
14 1
15 1
18 1
21 1
NA 268

Number of Updates

Count of Versions Count of Studies
1 146
2 119
3 123
4 139
5 99
6 80
7 63
8 43
9 22
10 28
11 19
12 11
13 15
14 10
15 12
16 6
17 8
18 3
19 4
20 5
21 6
22 6
23 3
24 5
25 2
26 2
27 4
28 2
29 1
30 3
31 4
32 3
35 3
36 1
37 3
38 3
39 1
40 2
41 2
42 2
43 1
44 2
45 1
46 1
47 1
48 2
52 1
53 2
54 1
55 2
59 1
60 1
65 1
66 2
67 1
68 1
72 2
82 1
96 1
99 1
111 1
114 1
182 1
189 1

Update History Change Type

Change Type Count_of_Changes Count_of_Studies ratio
Study Status 7615 897 8.489409
Contacts/Locations 2848 721 3.950069
Recruitment Status 1364 699 1.951359
None (earliest Version on record) 1043 1043 1.000000
Study Design 1028 622 1.652733
Outcome Measures 878 421 2.085511
Sponsor/Collaborators 753 444 1.695946
Study Identification 733 437 1.677345
Study Description 610 337 1.810089
Arms 609 340 1.791176
Interventions 609 340 1.791176
Eligibility 601 325 1.849231
Oversight 465 365 1.273973
Conditions 458 270 1.696296
More Information 354 109 3.247706
References 347 245 1.416327
Results 162 162 1.000000
IPDSharing 105 88 1.193182
Baseline Characteristics 90 65 1.384615
Participant Flow 82 62 1.322581
Reported Adverse Events 70 55 1.272727
Results Submission Events 65 65 1.000000
Documents 63 57 1.105263

Enrollment Metrics by Phase

Measure Early.Phase.1 N.A Phase.1 Phase.1.Phase.2 Phase.2 Phase.2.Phase.3 Phase.3 Phase.4
Min. 6.00000 4.0000 5.00000 10.00000 5.0000 30.000 1.0000 10.0000
1st Qu. 11.25000 70.0000 18.00000 20.00000 44.5000 63.500 146.7500 33.0000
Median 26.50000 229.0000 30.00000 30.00000 90.0000 157.500 313.0000 88.0000
Mean 60.83333 870.1261 43.02358 71.74074 225.2312 1385.833 716.7153 526.1266
3rd Qu. 66.50000 531.0000 48.00000 96.00000 179.0000 1786.000 645.5000 225.0000
Max. 220.00000 25000.0000 500.00000 333.00000 5029.0000 12000.000 10000.0000 18696.0000

Trial Group Type

group_type Group_Count
Experimental 1152
Active Comparator 312
NA 268
No Intervention 143
Placebo Comparator 114
Other 79
Sham Comparator 4

Intervention Model

intervention_model Study_Count
Parallel Assignment 505
Single Group Assignment 231
NA 189
Crossover Assignment 79
Factorial Assignment 25
Sequential Assignment 14

Primary Purpose

primary_purpose Study_Count
Treatment 601
Prevention 196
Health Services Research 54
Supportive Care 50
Other 42
NA 37
Basic Science 35
Diagnostic 14
Screening 11
Device Feasibility 2
Educational/Counseling/Training 1

Observational Studies

Studies by Country

Country Study_Count
United States 87
NA 38
Thailand 8
Canada 6
France 6
Germany 6
Spain 6
Uganda 6
China 5
Brazil 4
Swaziland 4
Taiwan 4
United Kingdom 4
Ghana 3
Italy 3
Japan 3
Kenya 3
Korea, Republic of 3
Lesotho 3
South Africa 3
United States|Puerto Rico 3
United States|Canada 2
Argentina 1
Argentina|Brazil|Mexico 1
Australia 1
Cameroon|Kenya|Lesotho|Swaziland|Uganda 1
Ecuador|Peru 1
Ethiopia 1
Finland|Ireland|Netherlands|Portugal|Switzerland 1
Hong Kong 1
India 1
Indonesia 1
Israel 1
Kenya|South Africa 1
Netherlands 1
Nigeria 1
Poland 1
Russian Federation 1
Rwanda|South Africa 1
Switzerland 1
Tanzania 1
Uganda|Zimbabwe 1
United States|Australia|Brazil|Canada|Zimbabwe 1
United States|Belgium|Brazil|Canada|France|Germany|Greece|Italy|Puerto Rico|Spain|United Kingdom 1
United States|Brazil|Peru|South Africa 1
United States|India|Kenya|Thailand 1
United States|Malawi|South Africa|Tanzania|Uganda 1
Vietnam 1
Zambia 1
Zimbabwe 1

Sites per Study

Site_count Study_Count
1 172
2 8
3 8
4 5
5 6
6 3
7 1
8 6
9 4
10 2
11 1
12 3
13 1
14 1
15 2
17 1
18 2
19 1
20 2
21 1
23 2
29 1
30 1
34 1
38 1
90 1
267 1

Number of Updates

Count of Versions Count of Studies
1 28
2 32
3 58
4 19
5 15
6 14
7 10
8 6
9 7
10 10
11 2
12 7
13 2
14 3
15 1
16 2
17 4
20 2
23 1
24 1
25 1
27 3
30 1
33 2
46 1
56 1
67 1
71 1
106 1
125 1
152 1

Update History Change Type

Change Type Count_of_Changes Count_of_Studies ratio
Study Status 1741 210 8.290476
Contacts/Locations 508 150 3.386667
Study Design 281 154 1.824675
Recruitment Status 259 160 1.618750
None (earliest Version on record) 238 238 1.000000
Study Description 223 83 2.686747
Eligibility 161 103 1.563107
Sponsor/Collaborators 160 89 1.797753
Study Identification 131 89 1.471910
Conditions 90 53 1.698113
Outcome Measures 90 66 1.363636
Groups 87 62 1.403226
Interventions 87 62 1.403226
References 85 50 1.700000
Oversight 77 66 1.166667
Results 19 19 1.000000
IPDSharing 12 12 1.000000
More Information 7 5 1.400000
Results Submission Events 4 4 1.000000
Documents 3 3 1.000000
Baseline Characteristics 1 1 1.000000

Enrollment Metrics

Measure Observational
Min 0.0000
1st Qu 56.2500
Median 200.0000
Mean 987.0676
3rd Qu 531.0000
Max 40000.0000

Observation Model

observational_model Study_Count
Cohort 124
NA 51
Case-Only 20
Other 14
Case-Control 13
Case Control 12
Defined Population, Natural History 2
Natural History 2

Time Perspective

time_perspective Study_Count
Prospective 136
Cross-Sectional 35
NA 35
Retrospective 21
Other 8
Longitudinal, Prospective 2
Cross-Sectional, Retrospective/Prospective 1

Registries

Studies by Country

Country Study_Count
United States 3
Brazil 1
Ethiopia 1
France 1
Mexico 1
NA 1
Spain 1
Tanzania 1

Sites per Study

Site_count Study_Count
1 8
4 1
6 1

Number of Updates

Count of Versions Count of Studies
1 2
2 3
3 1
4 1
6 1
7 1
13 1

Update History Change Type

Change Type Count_of_Changes Count_of_Studies ratio
Study Status 31 8 3.875000
None (earliest Version on record) 10 10 1.000000
Study Design 9 6 1.500000
Contacts/Locations 8 4 2.000000
Recruitment Status 7 7 1.000000
Sponsor/Collaborators 7 3 2.333333
Conditions 5 2 2.500000
Eligibility 4 2 2.000000
Study Description 4 2 2.000000
Study Identification 4 2 2.000000
References 3 2 1.500000
Outcome Measures 2 2 1.000000
Oversight 2 1 2.000000
Groups 1 1 1.000000
Interventions 1 1 1.000000

Enrollment Metrics

Measure Registries
Min 1.00
1st Qu 132.75
Median 353.00
Mean 903.40
3rd Qu 1147.50
Max 3760.00

Registry Model

observational_model Study_Count
Cohort 3
Ecologic or Community 3
Other 2
Case-Only 1
Case Control 1

Time Perspective

time_perspective Study_Count
Prospective 10

Follow-up

target_duration Study_Count
1 Year 2
1 Day 1
1 Month 1
12 Months 1
24 Months 1
3 Years 1
31 Years 1
6 Months 1
7 Months 1